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Agonist receptors are proteins located on the surface of cells that bind to specific molecules, called agonists, and trigger a cellular response. Agonist receptors can be found in various types of cells in the body and play important roles in regulating physiological functions such as neurotransmission, hormone secretion, and immune responses.
When an agonist binds to an agonist receptor, it activates the receptor, which initiates a series of biochemical signals inside the cell that ultimately lead to a physiological response. This response can be a change in the permeability of the cell membrane, activation of enzymes, or activation of intracellular signaling pathways.
Agonist receptors can be classified into different subtypes based on their molecular structure and the type of agonist they bind to. Some common examples of agonist receptors include:
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- Adrenergic receptors: These receptors bind to adrenaline and other catecholamines and play a role in regulating the sympathetic nervous system.
- Opioid receptors: These receptors bind to opioids such as morphine and play a role in regulating pain perception.
- Dopamine receptors: These receptors bind to dopamine and play a role in regulating reward, motivation, and motor function.
- Serotonin receptors: These receptors bind to serotonin and play a role in regulating mood, appetite, and sleep.
Agonist receptors are important targets for drug development, as drugs that bind to these receptors can either activate or block their function, leading to therapeutic effects in various diseases and conditions.